Systematic review and meta-analysis
UK National Screening Committee (UK NSC)
Syphilis is a sexually transmitted infection which can cause serious and long-term health problems if left untreated. However, enough treatment at the right time, the infection can be cured, and long-term complications prevented. Syphilis develops in stages, and treatment will vary according to the stage of the disease. In pregnant women, treatment also varies according to the stage of pregnancy they are in.
If untreated in pregnancy, syphilis can lead to very serious complications including loss of the pregnancy, still birth, premature delivery, and death of the baby shortly after birth.
To advise UK NSC whether health services in the UK should offer an additional screen for syphilis in the third trimester of pregnancy based on updating the UK NSC 2020 cost-effectiveness model in this population group.
Chief Investigators: Dr Harry Hill, Dr Olena Mandrik